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wiesje van de flier

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10 april 2013, 11:06
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NOS Journaal 04-04-2013



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BenJenkins (11 april 2013)
10 april 2013, 11:06
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bd
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Name : Wiesje van der Flier
Department : Alzheimer Center, department of Neurology
Position : Head Research Alzheimer Center (universitair docent)
CURRICULUM VITAE
Wiesje M. van der Flier (1975) studied neuropsychology at the Universiteit Utrecht (graduation: 1999). The subject of her thesis was “MRI correlates of cognitive decline”(Leiden University Medical Center, date of defence: 2004). She started her post doc position in the Alzheimer center VUmc in 2004. She holds a part time position as universitair docent at the department of epidemiology and biostatistics since 2008. In 2008 she took the position of Head Research of the Alzheimer center (universitair docent). This means coordination of clinical research and supervision of the PhD students of the Alzheimer center VUmc.
CURRENT PROJECTS
The research of the Alzheimer center VUmc has three main themes:
  1. Endophenotypes of dementia; early onset Alzheimer’s disease, other types of dementia, meaningful subtypes. Towards understanding heterogeneity.
  2. Early diagnosis; biomarkers for sensitive and specific diagnosis, recognize incipient Alzheimer’s disease (in mild cognitive impairment, subjective complaints). Discriminate different types of dementia. In addition; finding biomarkers for prognosis and to monitor disease progression.
  3. Vascular factors; dementia at old age is often caused by mixed pathology. This research line studies how vascular disease and neurodegenerative braing changes interact to cause dementia.

KEY PUBLICATIONS
  • van der Flier WM, Pijnenburg YAL, Fox NC, Scheltens Ph. Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele. Lancet Neurol. 2010; Dec 22 (Epub ahead of print).
  • Cordonnier C, van der Flier WM. Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain 2011 Feb;134(Pt 2):335-44. Epub 2011 Jan 21
  • van der Vlies AE, Verwey NA, Bouwman FH, Blankenstein MA, Klein M, Scheltens P, van der Flier WM. CSF biomarkers in relationship to cognitive profiles in Alzheimer disease. Neurology 2009; 72(12):1056-1061.
  • Henneman WJ, Sluimer JD, Cordonnier C, Baak MM, Scheltens P, Barkhof F, van der Flier WM. MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population. Stroke 2009; 40(2):492-498.
  • Sluimer JD, Vrenken H, Blankenstein MA, Fox NC, Scheltens P, Barkhof F, van der Flier WM. Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors. Neurology 2008; 70(19 Pt 2):1836-1841.
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